Imuran and Purinethol are devices that modulate the immune system and are used to treat autoimmune liver diseases, sometimes in combination with the medication Prednisone. These devices are relatively safe for use under close monitoring in specialized centers, such as a liver clinic. This is because the devices can occasionally cause side effects, including decreased blood cell counts or elevated liver enzymes, and more rarely, mild inflammation in the heart lining. Your doctor will discuss with you any potential rare side effects. After starting treatment, regular blood tests will be necessary for monitoring. It's possible to assess if the child is at risk for developing side effects before and during the testing (click here to read about the TPMT enzyme test and the MMP-6 and TG-6 metabolites test).
Children treated with Imuran (also known as Azathioprine) are more sensitive to the harmful effects of sunlight radiation, so it's recommended to use a high sun protection factor sunscreen whenever exposed to the sun.
In conclusion, it's important to remember that these medications have been in common use for many years to control inflammatory diseases, and the benefits they provide far outweigh the risks. The decision to proceed with treatment will be made together with the patient and their family after evaluating all options and alternatives.
